Compositions and methods for treating inflammatory bowel disease and airway inflammation

US8906662B2 · kind B2 · utility

Assignee

• UNIVERSITY OF MARYLAND, BALTIMORE · US

Inventors

• James Nataro · Owings Mills, US
• Fernando Ruiz-Perez · Charlottesville, US

Key dates

• Filing date: Dec 22, 2010
• Grant date: Dec 9, 2014
• Expiry date: Dec 22, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C11D3/386
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compositions and methods for treating inflammation due to an immune response. Non-limiting example compositions include class-2 SPATE proteins that are capable of cleaving proteins involved in an inflammatory immune response in a patient. Example compositions include at least one mucin-cleaving class-2 SPATE protein. Further example compositions include protein involved in intestinal colonization (Pic). Non-limiting example methods include methods of decreasing inflammation in a patient having inflammation and methods of perturbing immune response in a patient having a disease or condition in which an active immune response is attributable to a cause of the disease or condition, by administering to the patient a composition including at least one class-2 SPATE protein capable of cleaving proteins involved in an inflammatory immune response.