Effective treatment of ovarian cancer using triciribine and related compounds
US8906869B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 8, 2013 |
| Grant date | Dec 9, 2014 |
| Priority date | — |
| Expiry date | Jul 8, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/57449
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug. The invention further encompasses a number of miRNAs, which are altered in human ovarian cancer, with the most significantly deregulated miRNAs being miR-214, -199a*, -200a, -100, -12Sb, and let-7 cluster. Further, the invention illustrates that frequent deregulation of miR-214, -199a*, -200a and -100 in ovarian cancers and their alterations are associated with high grade and late stage tumor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.