C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity

US8906889B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Jacob Swidorski · Wallingford, US
• Nicholas A. Meanwell · East Hampton, US
• Alicia Regueiro-Ren · Wallingford, US
• Sing-Yuen Sit · Meriden, US
• Jie Chen · Houston, US
• Yan Chen · Foster City, US

Key dates

• Filing date: Feb 6, 2013
• Grant date: Dec 9, 2014
• Expiry date: Mar 22, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J63/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV:wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.