Pyrido[4,3-B]indoles containing rigid moieties

US8906925B2 · kind B2 · utility

Assignee

• Medivation Technologies LLC · US

Inventors

• David Hung · Belmont, US
• Andrew Asher Protter · Palo Alto, US
• Rajendra Parasmal Jain · East Chicago, US
• Sarvajit Chakravarty · Sunnyvale, US

Key dates

• Filing date: Mar 8, 2013
• Grant date: Dec 9, 2014
• Expiry date: Mar 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.