Methods for producing transgenic rodents having recombinant immunoglobulin loci
US8907157B2 · kind B2 · utility
22Cited by
17References
10Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 5, 2010 |
| Grant date | Dec 9, 2014 |
| Priority date | — |
| Expiry date | Mar 21, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods for the production of transgenic animals comprising a recombinant Ig locus, as well as transgenic antibodies derived therefrom. The methods involve meganuclease cleavage-stimulated homologous recombination in mammalian embryos.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.