Patent · US Active

Transgenic plants expressing galactosyltransferase and sialyl transferase

US8907163B2 · kind B2 · utility

8Cited by

25References

13Claims

0Family size

Assignee

Stichting Dienst Landbouwkundig Onderzoek-PPO/PRI · NL

Inventors

Hendrikus Antonius Cornelis Bakker · Hannover, DE
Hendrik Jan Bosch · Utrecht, NL

Key dates

Filing date	Apr 27, 2012
Grant date	Dec 9, 2014
Priority date	—
Expiry date	May 23, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/8258
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these. The invention provides a plant comprising functional mammalian β1,4-galactosyltransferase and mammalian sialyl transferase for producing complex N-linked glycans that are galactosylated and sialylated, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.