Low-permeability, laser-activated drug delivery device

US8911426B2 · kind B2 · utility

Assignee

• On Demand Therapeutics, Inc. · US

Inventors

• Jonathan R. Coppeta · Windham, US
• Kenneth N. Horne · Palo Alto, US
• John T. Santini, Jr. · North Chelmsford, US
• John A. Scholl · San Ramon, US
• Gregory Spooner · Kensington, US
• Cynthia L. Stevenson · Mountain View, US
• Naveed Shams · Emeryville, US
• Andrew Poutiatine · Palo Alto, US

Key dates

• Filing date: Feb 8, 2011
• Grant date: Dec 16, 2014
• Expiry date: Feb 17, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F9/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.