Culture system and method for immunogenicity and immunofunction testing in vitro

US8911995B2 · kind B2 · utility

Assignee

• ProBioGen AG · DE

Inventors

• Richard Ammer · Iserlohn, DE
• Christian Demmler · Berlin, DE
• Uwe Marx · Postbauer-Heng, DE
• Annika Lubitz · Berlin, DE
• Michael Sacharjat · Berlin, DE
• Christoph Giese · Herford, DE

Key dates

• Filing date: Aug 21, 2008
• Grant date: Dec 16, 2014
• Expiry date: Mar 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12M35/08
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention provides a culture device comprising a plurality of culture units, wherein each unit comprises a culture chamber, an inlet port for liquid supply of the culture and an outlet port for discharging liquid from the unit, wherein the inlet port is in fluid communication with the culture chamber and the culture chamber is in fluid communication with the outlet port for allowing a liquid flow through the culture chamber. The culture device is particularly suitable for testing immune cells and immunofunction in vitro. Aspects of the invention include a culture device and associated methods for cultivating immune cells and an in vitro method of analysing the effect of a test compound on immune cells.