DNA-binding proteins and uses thereof

US8912138B2 · kind B2 · utility

Assignee

• Sangamo Biosciences, Inc. · US

Inventors

• Philip D. Gregory · Richmond, US
• Jeffrey C. Miller · Pleasanton, US
• David Paschon · Oakland, US
• Edward J. Rebar · Richmond, US
• Siyuan Tan · Richmond, US
• Fyodor Urnov · Richmond, US
• Lei Zhang · Beijing, CN

Key dates

• Filing date: Oct 28, 2013
• Grant date: Dec 16, 2014
• Expiry date: Oct 28, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/80
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomic editing of endogenous cellular sequences.