Rock inhibitors

US8912209B2 · kind B2 · utility

Assignee

• Amakem NV · BE

Inventors

• Dirk Leysen · Diepenbeek, BE
• Oliver Defert · Diepenbeek, BE
• Nadzeya Kaval · Diepenbeek, BE
• Petra Blom · Laarne, BE
• Sandro Boland · Diepenbeek, BE

Key dates

• Filing date: May 20, 2013
• Grant date: Dec 16, 2014
• Expiry date: May 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.