Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals

US8912224B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Werngard Czechtizky · Frankfurt, DE
• John Weston · Frankfurt am Main, DE
• Nils RACKELMANN · Frankfurt am Main, DE
• Michael PODESCHWA · Frankfurt am Main, DE
• Petra Arndt · Frankfurt am Main, DE
• Klaus Wirth · Frankfurt am Main, DE
• Heinz GOEGELEIN · Frankfurt, DE
• Olaf Ritzeler · Bad Soden, DE
• Volker Kraft · Frankfurt am Main, DE
• Patrice BELLEVERGUE · Paris, FR
• Gary MCCORT · Paris, FR

Key dates

• Filing date: Sep 12, 2011
• Grant date: Dec 16, 2014
• Expiry date: Jan 8, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I,in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.