Nucleobase-functionalized conformationally restricted nucleotides and oligonucleotides for targeting nucleic acids
US8912318B2 · kind B2 · utility
1Cited by
16References
20Claims
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Key dates
| Filing date | Jun 19, 2013 |
| Grant date | Dec 16, 2014 |
| Priority date | — |
| Expiry date | Jun 19, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Embodiments are disclosed herein that involve C5-functionalized nucleic acids, which can be used for detecting a target in a nucleic acid. Particular embodiments disclose methods for making these compounds, wherein the compounds can be formed by coupling of an intermediate with a linker. Certain embodiments disclose the use of these compounds for detecting single nucleotide polymorphisms, and for increasing the thermal affinity of nucleic acid complements as compared to unmodified nucleic acid complements. In addition, the disclosed compounds can decrease enzymatic degradation of nucleic acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.