Patent · US Active

Preparation of nucleosides ribofuranosyl pyrimidines

US8912321B2 · kind B2 · utility

24Cited by

6References

7Claims

0Family size

Assignee

Gilead Pharmasset LLC · US

Inventors

Steven D. Axt · San Jose, US
Keshab Sarma · Sunnyvale, US
Justin Vitale · San Mateo, US
Jiang Zhu · San Ramon, US
Bruce Ross · Carlsbad, US
Suguna Rachakonda · Copley, US
Quingwu Jin · San Jose, US
Byoung-Kwon Chun · Pleasanton, US

Key dates

Filing date	Oct 5, 2007
Grant date	Dec 16, 2014
Priority date	—
Expiry date	Apr 23, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/06
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present process provides an improved method for the preparation of 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-hydroxymethyl-3-methyl-tetrahydrofuran-2-yl)-1H-pyrimidin-2-one of the formula (IV) which is a potent inhibitor of Hepatitis C Virus (HCV) NS5B polymerase.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.