Composition for treatment of tuberculosis

US8912329B2 · kind B2 · utility

Assignee

• BIOVERSYS AG · CH

Inventors

• Ronald Schoenmakers · Bellinzona, CH
• Wilfried Weber · Wittlich, DE
• Marc Gitzinger · Laufenburg, CH
• Martin Fussenegger · Bellinzona, CH
• Marcel Tigges · Reinach, CH
• Peter Schneider · Königstein, DE

Key dates

• Filing date: Jun 25, 2010
• Grant date: Dec 16, 2014
• Expiry date: Jul 1, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a pharmaceutical composition comprising a compound of formula (1) wherein R1 is optionally substituted phenyl, optionally substituted pyridyl or optionally substituted indolyl; R2 is (CH2)n wherein n is 0, 1, 2, 3 or 4; R3 is (CH2)mR3A wherein m is 0, 1, 2, 3 or 4, and R3A is methyl, isopropyl, tert-butyl, OCH3, OH, optionally substituted phenoxy, C≡CH, C≡N, optionally substituted phenyl, furanyl or thienyl; A is a ring containing X1 with the meaning O, S, NH, N(CH3) or CH2; and X2 is O, S or NH; and a compound of formula (2) wherein R4 is optionally substituted phenyl, optionally substituted pyridyl, optionally substituted indolyl, —NR7R8; or —NH—N═CH—R9; and substituents R5 to R9 have the meanings indicated in the description, in particular ethionamide. The pharmaceutical composition is useful, e.g., in the treatment of multidrug-resistant tuberculosis.