Patent · US Active

Expression of cytosolic malic enzyme in transgenic Yarrowia to increase lipid production

US8916365B2 · kind B2 · utility

2Cited by

2References

19Claims

0Family size

Assignee

E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

Daniel Joseph Macool · Rutledge, US
Zhixiong Xue · Chadds Ford, US
Quinn Qun Zhu · West Chester, US

Key dates

Filing date	Mar 14, 2013
Grant date	Dec 23, 2014
Priority date	—
Expiry date	Mar 14, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y101/0104
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Transgenic Yarrowia species are disclosed herein that comprise a polynucleotide encoding a cytosolic malic enzyme, a lipid content that is at least about 35% by weight of the dry cell weight of the Yarrowia species, and an engineered polyunsaturated fatty acid (PUFA) biosynthetic pathway, wherein overexpression of the cytosolic malic enzyme increases lipid content.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.