Compounds and methods for inhibiting phosphate transport

US8916569B2 · kind B2 · utility

Assignee

• ARDELYX, INC. · US

Inventors

• Jason G. Lewis · Castro Valley, US
• Jeffrey W. Jacobs · Fremont, US
• Nicholas Reich · Berkeley, US
• Michael R. Leadbetter · Fremont, US
• Noah Bell · Fremont, US
• Han-Ting Chang · Livermore, US
• Tao Chen · 安丰镇, CN
• Marc Navre · Belmont, US
• Dominique Charmot · Campbell, US
• Christopher Carreras · Belmont, US
• Eric Labonte · Redwood City, US

Key dates

• Filing date: Jan 4, 2013
• Grant date: Dec 23, 2014
• Expiry date: Jan 4, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, A, R1 and R2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.