Bradykinin B1-antagonists

US8916589B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Norbert Hauel · Schemmerhofen, DE
• Angelo Ceci · Mittelbiberach, DE
• Enzo Cereda · Novi Ligure, IT
• Henri Doods · Warthausen, DE
• Ingo Konetzki · Warthausen, DE
• Juergen Mack · Biberach an der Riß, DE
• Henning Priepke · Warthausen, DE
• Annette Schuler-Metz · Ulm, DE
• Rainer Walter · Biberach, DE

Key dates

• Filing date: Aug 28, 2008
• Grant date: Dec 23, 2014
• Expiry date: May 4, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of general formula Iwherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.