Methods of making diastereomeric organic compounds

US8916701B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Daniel Robert Fandrick · Danbury, US
• Zhi-Hui Lu · Glen Allen, US
• Diana Reeves · New Milford, US
• Jonathan Timothy Reeves · Ridgefield, US
• Chris Hugh Senanayake · Brookfield, US
• Jinhua J. Song · Brewster, US
• Yongda Zhang · Sandy Hook, US

Key dates

• Filing date: Dec 15, 2011
• Grant date: Dec 23, 2014
• Expiry date: Dec 15, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a process for making diastereomeric compound of the formula (I):wherein m, n and R1 to R4 are as defined herein. The process of the invention provides the compound of formula (I) in high yield and substantially free of the corresponding diastereomers. The compounds of formula (I) prepared by the process of the invention are useful for making pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors.