Topical bioadhesive formulations
US8920782B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 9, 2005 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Apr 16, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/59
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.