Myostatin binding agents, nucleic acids encoding the same, and methods of treatment
US8920798B2 · kind B2 · utility
9Cited by
39References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 20, 2012 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Nov 20, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/475
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such as a polymer or an Fc domain. The binding agents of the present invention produced increased lean muscle mass when administered to animals and decreased fat to muscle ratios. Therapeutic compositions containing the binding agents of the present invention are useful for treating muscle-wasting disorders and metabolic disorders including diabetes and obesity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.