Paliperidone double-layered osmotic pump controlled release tablet and preparation method thereof

US8920835B2 · kind B2 · utility

Assignees

• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• QILU PHARMACEUTICAL CO., LTD. · CN

Inventors

• Yong Gan · Lo Wu, CN
• Chunliu Zhu · Shanghai, CN
• Qingmin Yang · Ann Arbor, US
• Jingyi Wang · Chengdu, CN
• Xiaoqing Zheng · Jinan, CN
• Li Gan · Ebikon, CH
• Xinxin Zhang · Nanhu, CN

Key dates

• Filing date: Nov 22, 2010
• Grant date: Dec 30, 2014
• Expiry date: Aug 10, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A paliperidone double-layered osmotic pump controlled release tablet and the preparation method thereof are disclosed. The double-layered osmotic pump controlled release tablet comprises a rigid membrane, a push layer, a drug layer, an isolation layer and an aesthetic coating, wherein the rigid membrane contains a semi-permeable polymer, a porogen and/or a plasticizer and has one or more drug release orifices on one end, the push layer comprises an expanding material, an osmotic agent, a binder, a colorant and a lubricant, the drug layer contains a pharmaceutically active ingredient, a hydrophilic polymer, an osmotic agent, a colorant, a lubricant and an antistatic agent, the isolation layer is located between the inner surface of the rigid membrane and the push layer, and contains a hydrophilic polymer. The paliperidone double-layered osmotic pump controlled release tablet shows an increasing drug release rate at early stage and keeps a constant drug release rate at later stage.