Method of assessing properties of mammalian cells, and method of diagnosing cancer using the same
US8921057B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 30, 2005 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Jan 30, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/574
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A CDK profile including a ratio of specific activities of two cyclin dependent kinases closely correlates with the malignancy grade and the presence/absence of the sensitivity to an irritant such as an anticancer agent of a cancer tissue in clinical medicine. Therefore, the properties of a mammalian cell, such as malignancy grade, proliferation potency, sensitivity to an irritant such as an anticancer agent can be assessed based on its CDK profile or by comparing the result of a specific activity ratio of two CDKs with a predetermined threshold corresponding to the ratio. This sensitivity assessing method shows a high ratio of correct assessing results particularly in positive or sensitivity and is useful in predicting efficacy of chemotherapy using the anticancer agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.