Method and apparatus for determining a probability of colorectal cancer in a subject
US8921074B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 10, 2009 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Jan 16, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of determining a probability that a human test subject has colorectal cancer as opposed to not having colorectal cancer is disclosed. The method comprises, for each gene of a set of one or more genes selected from the group consisting of ANXA3, CLEC4D, IL2RB, LMNB1, PRRG4, TNFAIP6 and VNN1: determining a level of RNA encoded by the gene in blood of the test subject, thereby generating test data; providing positive control data representing levels of RNA encoded by the gene in blood of human control subjects having colorectal cancer, and providing negative control data representing levels of RNA encoded by the gene in blood of human control subjects not having colorectal cancer; and determining a probability that the test data corresponds to the positive control data and not to the negative control data, where the probability that the test data corresponds to the positive control data and not to the negative control data represents the probability that the test subject has colorectal cancer as opposed to not having colorectal cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.