Arrangement for on-line measurements on cells

US8921093B2 · kind B2 · utility

Assignee

• BIOCER ENTWICKLUNGS-GMBH · DE

Inventors

• Daniel Seitz · Altstätten, CH
• Helmar Mayr · Kaufering, DE
• Guenter Ziegler · Polling, DE
• Winfried Vonau · Geringswalde, DE
• Frank Gerlach · Mississauga, CA
• Sigrun Herrmann · Hartha, DE

Key dates

• Filing date: Jul 23, 2007
• Grant date: Dec 30, 2014
• Expiry date: Jul 22, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01L2300/163
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to an arrangement (a measurement device) for on-line measurements on cells, in particular for measuring soluble analytes and dissolved gases on samples in a sample area.The object of the invention, to specify an arrangement for on-line measurements in order to investigate and monitor the metabolism of living cells, which avoids the disadvantages of the prior art and can be integrated in a microfluidic system in the process, is achieved in that the arrangement comprises a substrate, at least one sensor, a sample analysis space and a membrane with the substrate holding the sensor or the sensors and the membrane in such a way that the sample analysis space is generated between the sensor or sensors and the membrane, with the membrane having the capability to be connected in a biocompatible form and to a cell culture space with the sensor or sensors being electrochemical sensors, and in which the sample analysis space can be filled with a transfer medium and can be integrated in fluidic systems, and the sensor sensors is or are fitted with operating circuits via which downstream electronics can be coupled.