Nociceptin mimetics
US8921306B2 · kind B2 · utility
3Cited by
0References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 7, 2011 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Jun 7, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/575
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to nociceptin peptide mimetics that have α-helical structures and bind to and modulate the opioid receptor-like-1 (ORL-1) receptor. The peptide mimetics are constrained cyclic nociceptin analogs which have either agonist or antagonist activity. Pharmaceutical compositions comprising the nociceptin peptide mimetics and methods of treating or preventing a disease or condition ameliorated by modulating the ORL-1 receptor are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.