Nano-recombinant fibrinogen for fibrin sealants
US8921317B1 · kind B1 · utility
3Cited by
5References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 11, 2010 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Aug 7, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/56
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A fibrin-based hemostatic agent suitable for both civilian and military use is disclosed. The hemostatic agent comprises (i) nanoparticles to which a plurality of Knob-A recognition sequences are attached, and (ii) coiled-coils of recombinantly-produced human fibrinogen α and chains and the γ chain globular domain. A delivery system for the hemostatic agent also is disclosed, which additionally comprises means for delivering (i) and (ii) to a wound site. The delivery means may be a CO2 canister or a shaker jet.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.