Serine protease inhibitors

US8921319B2 · kind B2 · utility

Assignee

• THE MEDICINES COMPANY (LEIPZIG) GMBH · DE

Inventors

• Torsten Steinmetzer · Jena, DE
• Sebastian Saupe · Kaltennordheim, DE

Key dates

• Filing date: Jul 5, 2011
• Grant date: Dec 30, 2014
• Expiry date: Oct 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06078
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides methods of making and using compounds of the formula shown, which are inhibitors of human plasmin and plasma kallikrein. (Formula I) The compounds are useful for the prevention of blood loss, and as components of fibrin adhesives.