Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

US8921388B2 · kind B2 · utility

Assignees

• European Molecular Biology Laboratory · DE
• F. Hoffmann-La Roche AG · CH
• Savira pharmaceuticals GmbH · AT

Inventors

• Helmut Buschmann · Walheim, DE
• Andrea Wolkerstorfer · Wien, AT
• Oliver Szolar · Wien, AT
• Norbert Handler · Wien, AT
• Stephen Cusack · Seyssinet-Pariset, FR
• Mark Smith · Saffron Walden, GB
• Sung-Sau So · Verona, US

Key dates

• Filing date: Aug 5, 2013
• Grant date: Dec 30, 2014
• Expiry date: Aug 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound having the general formula (Di), (Dii), or (Diii), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof,which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.