Substituted pyrazoles as estrogen receptor ligands

US8921402B2 · kind B2 · utility

Assignee

• Karo Bio AB · SE

Inventors

• Joakim Löfstedt · Uppsala, SE
• Xiongyu Wu · Uppsala, SE
• Lars Krüger · Huddinge, SE

Key dates

• Filing date: Jan 10, 2014
• Grant date: Dec 30, 2014
• Expiry date: Jan 10, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a compound of formula (I) wherein G is a pyrazole ring as defined in the specification and R4, R5, R6 and R7 are as defined in the specification; or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt. The invention also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity.