Low temperature, single solvent process for the production of sucrose-6-ester
US8921540B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 11, 2010 |
| Grant date | Dec 30, 2014 |
| Priority date | — |
| Expiry date | Oct 3, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H13/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the preparation of a sucrose-6-ester is disclosed. In a first step of the method, sucrose in a polar aprotic solvent is reacted with an organotin-based acylation promoter. The water of reaction is removed at a temperature that does not exceed about 80° C. In one aspect, the water is removed by distillation of part of the polar aprotic solvent at reduced pressure. In a second step, a carboxylic acid anhydride is added. In one aspect, the resulting reaction mixture is maintained at a temperature of 10° C. or less for a period of time sufficient to produce a sucrose-6-ester. The sucrose-6-ester can be converted to sucralose.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.