Patent · US Active

4-substituted-cyclohexylamino-4-piperidinyl-acetamide antagonists of CCR2

US8921559B2 · kind B2 · utility

0Cited by

6References

8Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

James C. Lanter · Exton, US
Thomas P. Markotan · Morgantown, US
Nalin Subasinghe · Exton, US
Zhihua Sui · Flemington, US
Xuqing Zhang · Raritan, US

Key dates

Filing date	Nov 30, 2011
Grant date	Dec 30, 2014
Priority date	—
Expiry date	Apr 6, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention comprises compounds of Formula (I).wherein: R1, R2, R3, R4, X, Y, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.