1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof

US8921563B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Yunfeng Li · Beijing, CN
• Rifang Yang · Beijing, CN
• Youzhi Zhang · Beijing, CN
• Yongzhen Li · Beijing, CN
• Zengliang Jin · Beijing, CN
• Peng Li · New York, US
• Li Yuan · Suzhou, CN
• Liuhong Yun · Beijing, CN
• Nan Zhao · Beijing, CN
• Cheng Zhang · Dalian, CN
• Xiaodan Xu · Tangxia, CN
• Rusheng Zhao · Beijing, CN
• Hongxia Chen · Beijing, CN
• Rui Xue · Beijing, CN
• Juanjuan Qin · Beijing, CN
• Zhenzhen Wang · Zhejiang, CN
• Jiazhi Yao · Qingdao, CN

Key dates

• Filing date: Apr 8, 2011
• Grant date: Dec 30, 2014
• Expiry date: Apr 8, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof.The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.