Extracellular matrix based gastroesophageal junction reinforcement device

US8927003B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Stephen F. Badylak · Lafayette, US
• Thomas Gilbert · Leek Wootton, GB
• Alejandro Nieponice · Olavarría, AR

Key dates

• Filing date: May 16, 2011
• Grant date: Jan 6, 2015
• Expiry date: Apr 21, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.