Biocompatible, non-biodegradable, non-toxic polymer useful for nanoparticle pharmaceutical compositions

US8927023B2 · kind B2 · utility

Assignee

• Fresenius Kabi Oncology Ltd. · IN

Inventors

• Anand C. Burman · Ghaziabad, IN
• Rama Mukherjee · Sidhauli, IN
• Dhiraj Khattar · Manesar, IN
• Sanjoy Mullick · Brampton, CA
• Manu Jaggi · Barwala, IN
• Manoj Kumar Singh · Sayla, IN
• Mukesh Kumar · Tampa, US
• Deepak Prusthy · Ghaziabad, IN
• Pawan Kumar Gupta · Bengaluru, IN
• Rajendran Praveen · Ghaziabad, IN
• Shobhit Kumar Singh · Ghaziabad, IN

Key dates

• Filing date: Oct 2, 2012
• Grant date: Jan 6, 2015
• Expiry date: Oct 2, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F222/385
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidne (VP), N-Isopropylactylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.