Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof

US8927509B2 · kind B2 · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Hua Shi · Ithaca, US
• Albert J. T. Millis · Schenectady, US
• Kimi Nishikawa · Greenwich, US
• Prabhat Kumar Mallik · Watervliet, US

Key dates

• Filing date: May 20, 2009
• Grant date: Jan 6, 2015
• Expiry date: Sep 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.