Methods for detecting and reducing impurities of Lapatinib and salts thereof
US8927558B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | May 14, 2012 |
| Grant date | Jan 6, 2015 |
| Priority date | — |
| Expiry date | Jul 4, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N30/06
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound of formula (I) or a salt thereof:and analytical methods for identifying and quantifying such impurities of Lapatinib and salts thereof are provided. Also provided is Lapatinib containing less than about 0.05 percent of this and related impurities and methods for preparing such pure forms of Lapatinib.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.