Norepinephrine and selective serotonin receptor blocker and use thereof

US8927566B2 · kind B2 · utility

Assignee

• Beijing Medisan Technology Co., Ltd · CN

Inventors

• Mingxin Wang · 南口镇, CN
• Jinai Liu · 南口镇, CN
• Fan Yang · Brookline, US
• Ailing Wang · 南口镇, CN
• Jiguo Sun · 南口镇, CN
• Yan Wang · San Diego, US
• Jin Cui · 南口镇, CN
• Lei Ji · Jinan, CN

Key dates

• Filing date: Nov 21, 2012
• Grant date: Jan 6, 2015
• Expiry date: Nov 21, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a norepinephrine and selective serotonin receptor blocker and the use thereof. The norepinephrine and selective serotonin receptor blocker is a compound of formula I, or isomers, pharmaceutically acceptable salts or solvates thereof, wherein R1 is selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, C6-10 aralkyl, C6-10 arylalkoxy, C1-6 haloalkyl and C1-6 haloalkoxy; and R2 is one or more groups each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy. R3 is one or more groups each independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, nitro, cyano, amino, hydroxyl, C1-6 haloalkyl, and C1-6 haloalkoxy. The compound of the present invention is effective norepinephrine and selective serotonin receptor blocker.