Human serum albumin linkers and conjugates thereof
US8927694B2 · kind B2 · utility
15Cited by
130References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2009 |
| Grant date | Jan 6, 2015 |
| Priority date | — |
| Expiry date | Mar 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a human serum albumin (HSA) linker and HSA linker with binding, diagnostic, and therapeutic agents conjugated thereto. Also disclosed is a conjugate in which the HSA linker is covalently bonded to amino and carboxy terminal binding moieties that are first and second single-chain Fv molecules (scFvs). Exemplified conjugates are useful, e.g., in reducing tumor cell proliferation, e.g., for therapeutic therapeutic applications. Also disclosed are methods and kits for the diagnostic and therapeutic application of an HSA linker conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.