Imaging agents for detecting neurological dysfunction

US8932557B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Gang Chen · Sammamish, US
• Umesh B. Gangadharmath · Los Angeles, US
• Dhanalakshmi Kasi · Los Angeles, US
• Anjana Sinha · San Diego, US
• Wei Zhang · San Diego, US
• Kai Chen · Rockville, US
• Vani P. Mocharla · Los Angeles, US

Key dates

• Filing date: May 22, 2012
• Grant date: Jan 13, 2015
• Expiry date: Sep 9, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease.