Poly(vinyl ester) polymers for in vivo nucleic acid delivery
US8932572B2 · kind B2 · utility
2Cited by
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20Claims
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Key dates
| Filing date | Aug 23, 2012 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Aug 23, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.