Fusion proteins and methods of use
US8932598B2 · kind B2 · utility
14Cited by
25References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2013 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Jun 28, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/16234
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions that include a fusion protein comprising flagellin and at least one antigen that has an isoelectric point greater than about 7.0 and that is fused to at least one domain 3 of the flagellin activate Toll-like Receptor 5. Methods of stimulating an immune response, in particular, a protective immune response include administering a composition that includes an antigen fused to a loop of domain 3 of flagellin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.