Incorporation of particulate ceragenins in polymers
US8932614B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Aug 24, 2012 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Aug 24, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/404
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A composite that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 μm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.