Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations
US8932629B2 · kind B2 · utility
1Cited by
27References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 26, 2007 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Jan 8, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2054
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A particulate co-processed composition comprising microcrystalline cellulose and at least one sugar alcohol is disclosed. A preferred sugar alcohol is mannitol. The composition has an improved compactability profile, lubricant sensitivity, and ejection profile compared to microcrystalline cellulose and the at least one sugar alcohol, either alone or in combination as a simple dry blend, in the preparation of solid dosage formulations, such as tablets. Tablets comprising the particulate co-processed composition, an active, and, optionally, one or more other excipients, and method for their preparation, are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.