Methods and compositions for determining a graft tolerant phenotype in a subject

US8932808B1 · kind B1 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Minnie M. Sarwal · Portola Valley, US
• Elaine S. Mansfield · Sunnyvale, US
• Sophie Brouard · La Chapelle-sur-Erdre, FR
• Jean-Paul Soulillou · Nantes, FR

Key dates

• Filing date: Jan 20, 2005
• Grant date: Jan 13, 2015
• Expiry date: Nov 3, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Methods are provided for determining whether a subject has a graft tolerant phenotype. In practicing the subject methods, the expression of at least one gene in a sample from the subject, e.g., a blood sample, is assayed to obtain an expression evaluation for the at least one gene. The obtained expression evaluation is then employed to determine whether the subject has a graft tolerant phenotype. Also provides are compositions, systems and kits that find use in practicing the subject methods. The methods and compositions find use in a variety of applications, including the determination of an immunosuppressive therapy regimen.