Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
US8933018B2 · kind B2 · utility
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29Claims
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Key dates
| Filing date | Feb 6, 2012 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Feb 6, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/025
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.