Poly(acrylate) polymers for in vivo nucleic acid delivery
US8933047B2 · kind B2 · utility
1Cited by
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20Claims
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Key dates
| Filing date | Aug 23, 2012 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Feb 7, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08F220/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.