N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents

US8933065B2 · kind B2 · utility

Assignee

• The University of North Carolina at Chapel Hill · US

Inventors

• Harold Kohn · Chapel Hill, US
• Christophe Salomé · Colmar, FR
• Ki Duk Park · Daejeon, KR
• Elise Salomé-Grosjean · Colmar, FR

Key dates

• Filing date: Sep 17, 2010
• Grant date: Jan 13, 2015
• Expiry date: Jun 15, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A first aspect of the invention is a compound (sometimes also referred to herein as an “active agent” or “active compound”) of Formula I or Ia:or a pharmaceutically acceptable salt or prodrug thereof. Compositions thereof and methods of using the same (e.g. for the treatment of a neurological disease) are also described.