Methods of targeting PTEN mutant diseases and compositions therefor
US8933070B2 · kind B2 · utility
14Cited by
0References
17Claims
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Assignee
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Key dates
| Filing date | Jul 4, 2011 |
| Grant date | Jan 13, 2015 |
| Priority date | — |
| Expiry date | Jul 4, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are methods, uses and compositions for treating a patient with cancer wherein the cancer is characterized by a PTEN gene mutation. In particular embodiments, the methods comprise administering to the patient a composition comprising a therapeutically effective amount of a PLK4 antagonist, and identifying a patient that is likely to be responsive to PLK4 antagonist therapy, if PTEN gene mutation is present.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.