2-(4-substituted phenylamino) polysubstituted pyridine compounds as inhibitors of non-nucleoside HIV reverse transcriptase, preparation methods and uses thereof

US8933106B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Lan Xie · Chapel Hill, US
• Xingtao Tian · Beijing, CN
• Kuo-Hsiung Lee · Chapel Hill, US
• Shibo Jiang · Floral Park, US
• Hong Lu · Des Moines, US

Key dates

• Filing date: Sep 28, 2009
• Grant date: Jan 13, 2015
• Expiry date: Mar 11, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/74
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 2-(4-Substituted phenylamino) polysubstituted pyridine compounds as inhibitors of non-nucleoside HIV reverse transcriptase, preparation methods and uses thereof. Specifically, the invention relates to compounds of formula I or the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the description. The compounds of formula I of the invention are a type of anti-HIV active compounds having new backbone structure.