Patent · US Active

Process for preparing Bosentan monohydrate and it's intermediates

US8933226B2 · kind B2 · utility

0Cited by

0References

14Claims

0Family size

Assignee

ZACH SYSTEMS S.P.A. · IT

Inventors

Livius Cotarca · Palmanova, IT
Massimo Verzini · San Bonifacio, IT
Elisa Melotto · Lonigo, IT
Ivan Michieletto · Venezia, IT
Alfonso Melloni · Bresso, IT
Paolo Maragni · Mantova, IT
Raffaella Volpicelli · Vicenza, IT
Mauro Andretto · Este, IT
Corrado Colli · Pioltello, IT

Key dates

Filing date	Sep 22, 2011
Grant date	Jan 13, 2015
Priority date	—
Expiry date	Sep 22, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C31/202
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a process for preparing Bosentan Monohydrate; in particular, the present invention provides the preparation of the novel 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-pyrimidin-4-yl]-benzenesulfonamide sodium salt as an ethylene glycol solvate (Bosentan sodium salt ethylene glycol solvate), which is a useful intermediate for obtaining Bosentan Monohydrate in a pure form.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.